Nanoparticulates reduce tumor cell migration through affinity interactions with extracellular migrasomes and retraction fibers-Reference-Cited by-同舟云学术

Nanoparticulates reduce tumor cell migration through affinity interactions with extracellular migrasomes and retraction fibers

Published:2022 Issue:7 Volume:7 Page:779-789
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Cheng Yuxi¹²^ORCID,Ren Junji¹²,Fan Shumin¹²,Wu Peiyao¹²³,Cong Wenshu¹²,Lin Yuxing¹²,Lan Shaojie¹²,Song Siyang¹²,Shao Bin⁴,Dai Wenbing¹²,Wang Xueqing¹²^ORCID,Zhang Hua¹²,Xu Bo²,Li Wenzhe²^ORCID,Yuan Xia²,He Bing¹²,Zhang Qiang¹²³

Affiliation:

1. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China

2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

3. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

4. Department of Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital, Beijing 100142, China

Abstract

NPs bind to retraction fibers and migrasomes during tumor cell migration. Such Nano–ECM interactions could alter cell morphology, limit cell motion range, change cell adhesion and inhibit tumor cell metastasis in vitro and in vivo.

Funder

Natural Science Foundation of Beijing Municipality

Major State Basic Research Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NH/D2NH00067A

Reference51 articles.

1. Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment