Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex-Reference-Cited by-同舟云学术

Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

Published:2017 Issue:29 Volume:53 Page:4136-4139
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liu Suyan¹²³⁴⁵,Zheng Wei¹²³⁴⁵,Wu Kui¹²³⁴⁵^ORCID,Lin Yu¹²³⁴⁵,Jia Feifei¹²³⁴⁵,Zhang Yang¹²³⁴⁵,Wang Zhaoying¹²³⁴⁵,Luo Qun¹²³⁴⁵,Zhao Yao¹²³⁴⁵,Wang Fuyi¹²³⁴⁵^ORCID

Affiliation:

1. Beijing National Laboratory for Molecular Sciences

2. National Centre for Mass Spectrometry in Beijing

3. CAS Key Laboratory of Analytical Chemistry for Living Biosystems

4. Institute of Chemistry

5. Chinese Academy of Sciences

Abstract

A correlated ToF-SIMS and CLSM imaging strategy was developed to visualize the subcellular distribution of an organoruthenium anticancer complex, showing its accumulation in both cell membrane and nuclei and verifying its dual-targeting feature.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC01503H

Reference32 articles.

1. New trends for metal complexes with anticancer activity

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3. Bioorganometallic chemistry—from teaching paradigms to medicinal applications

4. Design of targeting ligands in medicinal inorganic chemistry

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