Diketopyrrolopyrrole-based fluorescence probes for the imaging of lysosomal Zn2+ and identification of prostate cancer in human tissue

Author:

Du Chenchen12345,Fu Shibo67895ORCID,Wang Xiaohua12345,Sedgwick Adam C.1101112ORCID,Zhen Wei12345,Li Minjie12345,Li Xinqiang13141516,Zhou Juan67895,Wang Zhong67895,Wang Hongyu12345ORCID,Sessler Jonathan L.12345ORCID

Affiliation:

1. Department of Chemistry

2. College of Science

3. Center for Supramolecular Chemistry & Catalysis

4. Shanghai University

5. Shanghai

6. Department of Urology

7. Shanghai Ninth People's Hospital

8. Shanghai Jiaotong University

9. School of Medicine

10. The University of Texas at Austin

11. Austin

12. USA

13. Pathology Department

14. First Affiliated Hospital of Zhengzhou University

15. Zhengzhou

16. P. R. China

Abstract

Diketopyrrolopyrrole-based fluorescent probes have been developed for the detection of low pH and Zn2+ in an AND logic fashion. They can discriminate between cancerous and healthy prostate tissue.

Funder

National Natural Science Foundation of China

National Institutes of Health

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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