Design and synthesis of a polyguanidium vector with enhanced DNA binding ability for effective gene delivery at a low N/P ratio-Reference-Cited by-同舟云学术

Design and synthesis of a polyguanidium vector with enhanced DNA binding ability for effective gene delivery at a low N/P ratio

Author:

Chen Zhiyong¹²³⁴⁵,Huang Wei¹²³⁴⁵,Zheng Nan⁶⁷⁸⁹¹⁰^ORCID,Bai Yugang¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Chemical Biology and Nanomedicine

2. State Key Laboratory of Chem/Biosensing and Chemometrics

3. Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology

4. College of Chemistry and Chemical Engineering

5. Hunan University

6. Department of Polymer Science and Engineering

7. School of Chemical Engineering

8. Dalian University of Technology

9. Dalian

10. China

Abstract

A polyguanidium polymer has extra affinity toward DNA and can mediate transfection efficiently at a low polymer to DNA ratio.

Funder

Hunan University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

Reference50 articles.

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