Synthesis and biological evaluation of N-alkyl naphthoimidazoles derived from β-lapachone against Trypanosoma cruzi bloodstream trypomastigotes-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of N-alkyl naphthoimidazoles derived from β-lapachone against Trypanosoma cruzi bloodstream trypomastigotes

Published:2017 Issue:5 Volume:8 Page:952-959
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

da Silva Ari Miranda¹²³⁴⁵,Araújo-Silva Leonardo¹²³⁴,Bombaça Ana Cristina S.⁶⁷⁸⁹⁴,Menna-Barreto Rubem F. S.⁶⁷⁸⁹⁴,Rodrigues-Santos Claudio Eduardo¹²³⁴,Buarque Ferreira Aurélio B.¹²³⁴,de Castro Solange L.⁶⁷⁸⁹⁴^ORCID

Affiliation:

1. Programa de Pós-Graduação em Química

2. UFRRJ

3. Seropédica

4. Brazil

5. Instituto de Pesquisas em Produtos Naturais

6. Laboratório de Biologia Celular

7. Instituto Oswaldo Cruz

8. FIOCRUZ

9. Rio de Janeiro

Abstract

The trypanocidal activity of N-hexyl naphthoimidazoles (and other N-alkyl-naphthoimidazoles) is demonstrated for the first time, supporting further studies for rational chemical optimization.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00069C

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