Identification of a rhodium(iii) complex as a Wee1 inhibitor againstTP53-mutated triple-negative breast cancer cells-Reference-Cited by-同舟云学术

Identification of a rhodium(iii) complex as a Wee1 inhibitor againstTP53-mutated triple-negative breast cancer cells

Published:2018 Issue:20 Volume:54 Page:2463-2466
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yang Guan-Jun¹²³⁴⁵,Zhong Hai-Jing¹²³⁴⁵,Ko Chung-Nga⁶⁷⁸⁵,Wong Suk-Yu⁶⁷⁸⁵,Vellaisamy Kasipandi⁶⁷⁸⁵,Ye Min⁹¹⁰¹¹¹²⁵,Ma Dik-Lung⁶⁷⁸⁵^ORCID,Leung Chung-Hang¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine

2. Institute of Chinese Medical Sciences

3. University of Macau

4. Macao

5. China

6. Department of Chemistry

7. Hong Kong Baptist University

8. Kowloon Tong

9. State Key Laboratory of Natural and Biomimetic Drugs

10. School of Pharmaceutical Sciences

11. Peking University

12. Beijing 100191

Abstract

The rhodium(iii) complex1was identified as a potent Wee1 inhibitorin vitroandin cellulo.

Funder

National Natural Science Foundation of China

Universidade de Macau

Hong Kong Baptist University

Fundo para o Desenvolvimento das Ciências e da Tecnologia

Health and Medical Research Fund

Research Grants Council, University Grants Committee

Natural Science Foundation of Guangdong Province

Innovation and Technology Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C7CC09384E

Reference36 articles.

1. Comprehensive molecular portraits of human breast tumours

2. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

3. Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome

4. Abrogation of the G2 Checkpoint by Inhibition of Wee-1 Kinase Results in Sensitization of p53-Deficient Tumor Cells to DNA-Damaging Agents

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