Synthesis and characterization of a novel [<sup>52</sup>Mn]Mn-labelled affibody based radiotracer for HER2+ targeting-Reference-Cited by-同舟云学术

Synthesis and characterization of a novel [⁵²Mn]Mn-labelled affibody based radiotracer for HER2+ targeting

Published:2023 Issue:16 Volume:10 Page:4734-4745
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Váradi Balázs¹²³,Brezovcsik Károly³,Garda Zoltán¹,Madarasi Enikő¹²,Szedlacsek Horea⁴,Badea Rodica-Aura⁴,Vasilescu Andrei-Mihai⁴,Puiu Adina-Gabriela⁴,Ionescu Aura Elena⁴,Sima Livia-Elena⁴,Munteanu Cristian V. A.⁴^ORCID,Călăraş Simona⁴,Vágner Adrienn⁵,Szikra Dezső⁵,Toàn Ngô Minh⁵^ORCID,Nagy Tibor⁶,Szűcs Zoltán³^ORCID,Szedlacsek Stefan⁴,Nagy Gábor⁵,Tircsó Gyula¹^ORCID

Affiliation:

1. Department of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary

2. Doctoral School of Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary

3. Institute for Nuclear Research, Bem tér 18/C, Debrecen, H-4026, Hungary

4. Institute of Biochemistry, 296 Splaiul Independentei, Bucharest, 060031, Romania

5. Scanomed Ltd, Nagyeredei krt 98, Debrecen, H-4032, Hungary

6. Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary

Abstract

Affibody linked to a rigid macrocyclic chelator derived form pyclen-3,9-diacetate (3,9-PC2A) labelled with [52Mn]Mn isotope appears to be a valuable tool for PET-based targeted molecular imaging.

Funder

Debreceni Egyetem

Richter Gedeon Talentum Alapítvány

National Research, Development and Innovation Office

Academia Româna

Magyar Tudományos Akadémia

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QI/D3QI00356F