Synthesis and characterization of a novel [52Mn]Mn-labelled affibody based radiotracer for HER2+ targeting

Author:

Váradi Balázs123,Brezovcsik Károly3,Garda Zoltán1,Madarasi Enikő12,Szedlacsek Horea4,Badea Rodica-Aura4,Vasilescu Andrei-Mihai4,Puiu Adina-Gabriela4,Ionescu Aura Elena4,Sima Livia-Elena4,Munteanu Cristian V. A.4ORCID,Călăraş Simona4,Vágner Adrienn5,Szikra Dezső5,Toàn Ngô Minh5ORCID,Nagy Tibor6,Szűcs Zoltán3ORCID,Szedlacsek Stefan4,Nagy Gábor5,Tircsó Gyula1ORCID

Affiliation:

1. Department of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary

2. Doctoral School of Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary

3. Institute for Nuclear Research, Bem tér 18/C, Debrecen, H-4026, Hungary

4. Institute of Biochemistry, 296 Splaiul Independentei, Bucharest, 060031, Romania

5. Scanomed Ltd, Nagyeredei krt 98, Debrecen, H-4032, Hungary

6. Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary

Abstract

Affibody linked to a rigid macrocyclic chelator derived form pyclen-3,9-diacetate (3,9-PC2A) labelled with [52Mn]Mn isotope appears to be a valuable tool for PET-based targeted molecular imaging.

Funder

Debreceni Egyetem

Richter Gedeon Talentum Alapítvány

National Research, Development and Innovation Office

Academia Româna

Magyar Tudományos Akadémia

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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