A metal-free protocol for the preparation of amines using ammonia borane under mild conditions

Author:

Li Xinmin12,Hu Yue2,Alenad Asma M.3,Zhou Bei2,Ma Zhuang2,Gao Jie2,Jagadeesh Rajenahally V.2ORCID,Beller Matthias2ORCID

Affiliation:

1. School of Pharmacy, Zunyi Medical University, Xuefu West Road 6, 563000, Zunyi, China

2. Leibniz-Leibniz-Institut für Katalyse e.V., Albert-Einstein-Straße 29A, 18059 Rostock, Germany

3. Chemistry Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Kingdom of Saudi Arabia

Abstract

A mild and convenient reductive amination protocol for the synthesis of structurally diverse secondary and tertiary amines as well as N-methylated products under metal-free conditions is presented.

Funder

Ministry of Health – Kingdom of Saudi Arabia

China Scholarship Council

National Natural Science Foundation of China

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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