ADME profiling, molecular docking, DFT, and MEP analysis reveal cissamaline, cissamanine, and cissamdine from <i>Cissampelos capensis</i> L.f. as potential anti-Alzheimer's agents-Reference-Cited by-同舟云学术

ADME profiling, molecular docking, DFT, and MEP analysis reveal cissamaline, cissamanine, and cissamdine from Cissampelos capensis L.f. as potential anti-Alzheimer's agents

Published:2024 Issue:14 Volume:14 Page:9878-9891
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Alhawarri Maram B.¹^ORCID,Al-Thiabat Mohammad G.²,Dubey Amit³⁴,Tufail Aisha⁴,Fouad Dania⁵,Alrimawi Bilal Harieth⁶,Dayoob Mohamad⁷

Affiliation:

1. Department of Pharmacy, Faculty of Pharmacy, Jadara University, P.O.Box 733, Irbid 21110, Jordan

2. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor 11800, Penang, Malaysia

3. Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai-600077, Tamil Nadu, India

4. Computational Chemistry and Drug Discovery Division, Quanta Calculus, Greater Noida-201310, Uttar Pradesh, India

5. Faculty of Dentistry, Ibn Sina University for Medical and Pharmaceutical Sciences, Baghdad, Iraq

6. Michael Sayegh Faculty of Pharmacy, Aqaba University of Technology, Aqaba, Jordan

7. Faculty of Pharmacy, MAHSA University, Jenjarom, Malaysia

Abstract

Proaporphine alkaloids—cissamaline, cissamanine, and cissamdine—show promise against AD, with in silico studies highlighting their potential as new therapeutics.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01070A

Reference109 articles.

1. In Silico Molecular Docking Analysis of Karanjin against Alzheimer’s and Parkinson’s Diseases as a Potential Natural Lead Molecule for New Drug Design, Development and Therapy

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3. Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

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