Total synthesis of the antibacterial polyketide natural product thailandamide lactone-Reference-Cited by-同舟云学术

Total synthesis of the antibacterial polyketide natural product thailandamide lactone

Published:2022 Issue:45 Volume:13 Page:13403-13408
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sharma Himangshu¹,Mondal Joyanta¹,Ghosh Ananyo K.²,Pal Ritesh Ranjan²^ORCID,Goswami Rajib Kumar¹^ORCID

Affiliation:

1. School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India

2. School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India

Abstract

A convergent strategy for the total synthesis of the structurally intriguing polyketide natural product thailandamide lactone has been developed for the first time. The antibacterial activity of the molecule has also been disclosed.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC04727F

Reference43 articles.

1. Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

2. Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

3. Assembly and Absolute Configuration of Short-Lived Polyketides fromBurkholderia thailandensis

4. The Polyene Natural Product Thailandamide A Inhibits Fatty Acid Biosynthesis in Gram-Positive and Gram-Negative Bacteria

5. Cyclodepsipeptide alveolaride C: total synthesis and structural assignment

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