Multivalency effects on Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA-Reference-Cited by-同舟云学术

Multivalency effects on Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA

Published:2016 Issue:1 Volume:14 Page:138-148
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bergmann Myriam¹²³⁴,Michaud Gaëlle¹²³⁴,Visini Ricardo¹²³⁴,Jin Xian¹²³⁴,Gillon Emilie⁵⁶⁷⁸⁹,Stocker Achim¹²³⁴,Imberty Anne⁵⁶⁷⁸⁹,Darbre Tamis¹²³⁴,Reymond Jean-Louis¹²³⁴

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of Berne

3. 3012 Berne

4. Switzerland

5. Centre de Recherches sur les Macromolécules Végétales

6. UPR5301

7. CNRS and Université Grenoble Alpes

8. F38041 Grenoble

9. France

Abstract

The octagalactosylated G3 peptide dendrimer GalAxG3 was obtained by convergent synthesis, bound tightly to lectin LecA, and showed strong Pseudomonas aerguinosa biofilm inhibition and dispersal activity.

Funder

European Cooperation in Science and Technology

Swiss National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB01682G

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1. P. aeruginosa Biofilms in CF Infection

2. Novel approaches to the treatment ofPseudomonas aeruginosainfections in cystic fibrosis