Expanding the scope of fused pyrimidines as kinase inhibitor scaffolds: synthesis and modification of pyrido[3,4-d]pyrimidines
Author:
Affiliation:
1. Cancer Research UK Centre for Cancer Therapeutics
2. The Institute of Cancer Research
3. Surrey
4. UK
Abstract
A versatile and efficient entry into 2-amino-pyrido[3,4-d]pyrimidines was developed. Our strategy hinges on the concise preparation and derivatisation of 8-chloro-2-(methylthio)pyrido[3,4-d]pyrimidine intermediates to yield putative kinase inhibitors.
Funder
Cancer Research UK
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02238F
Reference16 articles.
1. Targeting cancer with small molecule kinase inhibitors
2. Targeting protein kinases in cancer therapy: a success?
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4. Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors
5. Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors
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