Development of an efficient route to CF3-substituted pyrrolopyrimidines through understanding the competition between Michael and aza-Henry reactions
Author:
Affiliation:
1. Institute of Organic Chemistry
2. National Academy of Sciences of Ukraine
3. Kyiv
4. Ukraine
5. Department of Chemistry
6. Lomonosov Moscow State University
7. 119899 Moscow
8. Russia
Abstract
A simple control of temperature and time in the nitromethane addition to 4-trifluoromethylated pyrimidin-2-ones allowed regioselective synthesis of isomeric products.
Funder
Russian Foundation for Basic Research
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02233E
Reference46 articles.
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4. Recent synthetic developments in the nitro to carbonyl conversion (Nef reaction)
5. Nitro-Mannich Reaction
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