A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes-Reference-Cited by-同舟云学术

A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes

Published:2016 Issue:3 Volume:7 Page:484-494
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Tassini Sabrina¹²³⁴,Castagnolo Daniele⁵⁶⁷⁸⁹,Scalacci Nicolò⁵⁶⁷⁸⁹,Kissova Miroslava¹⁰¹¹⁴,Armijos-Rivera Jorge I.¹⁰¹¹⁴,Giagnorio Federica¹²³⁴⁹,Maga Giovanni¹⁰¹¹⁴,Costantino Gabriele¹²³⁴,Crespan Emmanuele¹⁰¹¹⁴,Radi Marco¹²³⁴

Affiliation:

1. P4T Group, Dipartimento di Farmacia

2. Università degli Studi di Parma

3. 43124 Parma

4. Italy

5. Institute of Pharmaceutical Science

6. King's College London

7. SE1 9NH London

8. UK

9. Northumbria University Newcastle

10. Istituto di Genetica Molecolare

11. 27100 Pavia

Abstract

Herein we report the development of a new versatile chemical tool for the rapid identification of LRRK2-targeting probes as potential anti-Parkinson's agents.

Funder

Chiesi Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C5MD00462D

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