Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane-Reference-Cited by-同舟云学术

Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane

Published:2015 Issue:13 Volume:3 Page:2590-2598
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Dandekar P.¹²³⁴⁵,Jain R.¹²³⁴⁵,Keil M.⁶⁷⁴⁵⁸,Loretz B.¹²³⁴⁵,Koch M.⁹¹⁰¹¹⁴⁵,Wenz G.⁶⁷⁴⁵⁸,Lehr C.-M.¹²³⁴⁵

Affiliation:

1. Department of Drug Delivery (DDEL)

2. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)

3. Campus A4 1

4. Saarland University

5. Saarbrücken

6. Organic Macromolecular Chemistry

7. Campus C4 2

8. Germany

9. Innovative Electron Microscopy

10. INM-Leibniz Institute for New Materials

11. Campus D2 2

Abstract

Cellular investigations confirm the ability of cyclodextrin polyrotaxane nanoplexes to deliver siRNA for down-regulating genes relevant to the pathogenesis of tuberculosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TB/C4TB01821D

Reference35 articles.

1. Polymer systems for gene delivery—Past, present, and future

2. Polyrotaxanes for applications in life science and biotechnology

3. Polyrotaxane/DNA Conjugate by Use of Intercalation: Bridge Formation between DNA Double Helices

4. Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery

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