The role of acetylated cyclooxygenase-2 in the biosynthesis of resolvin precursors derived from eicosapentaenoic acid-Reference-Cited by-同舟云学术

The role of acetylated cyclooxygenase-2 in the biosynthesis of resolvin precursors derived from eicosapentaenoic acid

Published:2022 Issue:6 Volume:20 Page:1260-1274
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cebrián-Prats Anna¹^ORCID,Pinto Alexandre²^ORCID,González-Lafont Àngels¹³^ORCID,Fernandes Pedro A.²^ORCID,Lluch José M.¹³^ORCID

Affiliation:

1. Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

2. LAQV-Requimte, Faculty of Sciences, University of Porto, Rua do Campo Alegre S/N, Porto, Portugal

3. Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

Abstract

Aspirin-acetylated COX-2, but not COX-2, triggers the biosynthesis of anti-inflammatory E-series resolvins. The role of aspirin in the molecular mechanism of resolvin formation from EPA is revealed by MD simulations and QM/MM calculations.

Funder

Ministerio de Ciencia, Innovación y Universidades

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB01932E

Reference48 articles.

1. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

2. Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?

3. Resolvins and Protectins in Inflammation Resolution

4. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

5. New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

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