Organocatalytic enantioselective synthesis of Csp2–N atropisomers via formal Csp2–O bond amination-Reference-Cited by-同舟云学术

Organocatalytic enantioselective synthesis of C_sp₂–N atropisomers via formal C_sp₂–O bond amination

Published:2024 Issue:11 Volume:15 Page:3893-3900
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Qian Chenxiao¹²,Huang Jing²,Huang Tingting¹,Song Lijuan³^ORCID,Sun Jianwei²^ORCID,Li Pengfei¹^ORCID

Affiliation:

1. Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, College of Science, Southern University of Science and Technology Guangming Advanced Research Institute, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China

2. Department of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

3. School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China

Abstract

An organocatalyzed asymmetric synthesis of Csp2–N atropisomers by formal Csp2–O amination has been established from 3-alkynyl-3-hydroxyisoindolinones and 1-methylnaphthalen-2-ols.

Funder

Guangdong Provincial Key Laboratory Of Catalysis

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC06707F

Reference68 articles.

1. Atroposelective Synthesis of Axially Chiral Biaryl Compounds

2. Construction of Axially Chiral Compounds via Asymmetric Organocatalysis

3. Chiral Transient Directing Groups in Transition-Metal-Catalyzed Enantioselective C–H Bond Functionalization

4. Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications

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