Synthetic studies on the indane SHIP1 agonist AQX-1125-Reference-Cited by-同舟云学术

Synthetic studies on the indane SHIP1 agonist AQX-1125

Published:2022 Issue:19 Volume:20 Page:4016-4020
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Dungan Otto M.¹,Dormann Shawn¹,Fernandes Sandra²^ORCID,Duffy Brian C.¹,Effiong Daniel G.¹,Kerr William G.¹²³^ORCID,Chisholm John D.¹^ORCID

Affiliation:

1. Department of Chemistry, Syracuse University, 1-014 Center for Science and Technology, Syracuse, NY 13244, USA

2. Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

3. Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA

Abstract

A new synthesis of the indane based SHIP1 agonist AQX-1125 was developed. Testing of AQX-1125 and some analogs provides information on the pharmacophore and bioactivity.

Funder

National Institute on Aging

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00555G

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