A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate-Reference-Cited by-同舟云学术

A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate

Published:2018 Issue:7 Volume:9 Page:1105-1113
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Riley Andrew M.¹²³⁴⁵^ORCID,Unterlass Judith E.⁶⁷⁸⁹¹⁰^ORCID,Konieczny Vera²¹¹¹²⁵,Taylor Colin W.²¹¹¹²⁵^ORCID,Helleday Thomas⁶⁷⁸⁹¹⁰,Potter Barry V. L.¹²³⁴⁵^ORCID

Affiliation:

1. Medicinal Chemistry and Drug Discovery

2. Department of Pharmacology

3. University of Oxford

4. Oxford OX1 3QT

5. UK

6. Science for Life Laboratory

7. Department of Oncology-Pathology

8. Karolinska Institutet

9. SE-171 21 Solna

10. Sweden

11. University of Cambridge

12. Cambridge CB2 1PD

Abstract

We describe the synthesis and biological evaluation of 1-PP-Ins(4,5)P₂, the first diphosphate-containing analogue of the intracellular signalling molecule Ins(1,4,5)P₃.

Funder

Pain Relief Foundation

Cancerfonden

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00149A

Reference51 articles.

1. The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo-Inositol Chemistry)