Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue

Author:

Bood Mattias1234ORCID,Füchtbauer Anders F.5634ORCID,Wranne Moa S.5634ORCID,Ro Jong Jin7891011,Sarangamath Sangamesh5634,El-Sagheer Afaf H.1213141516ORCID,Rupert Déborah L. M.1718634,Fisher Rachel S.19202122,Magennis Steven W.2319242522ORCID,Jones Anita C.19202122,Höök Fredrik1718634ORCID,Brown Tom726272822ORCID,Kim Byeang Hyean7891011ORCID,Dahlén Anders293031324,Wilhelmsson L. Marcus5634ORCID,Grøtli Morten1234ORCID

Affiliation:

1. Department of Chemistry and Molecular Biology

2. University of Gothenburg

3. SE-412 96 Gothenburg

4. Sweden

5. Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry

6. Chalmers University of Technology

7. Department of Chemistry

8. Division of Advanced Materials Science

9. Pohang University of Science and Technology (POSTECH)

10. Pohang 37673

11. South Korea

12. Chemistry Branch

13. Faculty of Petroleum and Mining Engineering

14. Suez University

15. Suez 43721

16. Egypt

17. Division of Biological Physics

18. Department of Physics

19. School of Chemistry

20. University of Edinburgh

21. Edinburgh EH9 3JJ

22. UK

23. WestCHEM

24. University of Glasgow

25. Glasgow

26. Chemistry Research Laboratory

27. University of Oxford

28. Oxford

29. AstraZeneca R&D

30. Innovative Medicines

31. Cardiovascular & Metabolic Diseases (CVMD)

32. Gothenburg

Abstract

A highly fluorescent, non-perturbing, pentacyclic adenine analog was designed, synthesized, incorporated into DNA and photophysical evaluated.

Funder

Vetenskapsrådet

Stiftelsen för Strategisk Forskning

National Research Foundation of Korea

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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