Synthetic versatility of 2-substituted-6-methyl 2,3-dihydropyridinones in the synthesis of polyfunctional piperidine-based compounds and related β amino acid derivatives

Author:

Yang Yang123ORCID,Hardman Clayton123ORCID

Affiliation:

1. Genomics Institute of the Novartis Research Foundation

2. San Diego

3. USA

Abstract

Synthetic versatility of chiral 2-substituted-6-methyl 2,3-dihydropyridinones in the synthesis of chiral polyfunctional piperidine and β amino acid derivatives.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference98 articles.

1. P. M. Dewick , in Medicinal Natural Products. A biosynthestic approach, Wiley, 3rd revised edn, 2002

2. E. Szoke , E.Lemberkovics and L.Kursinszki, in Natural Products, Alkaloids Derived from Lysine: Piperidine Alkaloids, ed. K. G. Ramawat and J. M. Merillon, Springer, 2013, pp. 301–343

3. R. Vandanyan , in Piperidine-based drug discovery, Elsevier, 2017

4. Rings in Drugs

5. Stereoselective Synthesis of 2,6-cis- and 2,6-trans-Piperidines through Organocatalytic Aza-Michael Reactions: A Facile Synthesis of (+)-Myrtine and (−)-Epimyrtine

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