Coaxial bioprinting of a stentable and endothelialized human coronary artery-sized in vitro model

Author:

Ahmad Ashfaq12,Kim Seon-Jin3ORCID,Jeong Yun-Jin4,Khan Muhammad Soban5,Park Jinsoo5ORCID,Lee Dong-Weon5,Lee Changho67,Choi Yeong-Jin89,Yi Hee-Gyeong12ORCID

Affiliation:

1. Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea

2. Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Republic of Korea

3. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, 37666, Republic of Korea

4. Department of Automatic System, Chosun College of Science & Technology, Gwangju, 61453, Republic of Korea

5. Department of Mechanical Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea

6. Department of Artificial Intelligence Convergence, Chonnam National University, Gwangju, 61186, Republic of Korea

7. Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, 58128, Republic of Korea

8. Bio and Healthcare Materials Research Division, Korea Institute of Materials Science (KIMS), Changwon, 51508, Republic of Korea

9. Advanced Materials Engineering, Korea National University of Science and Technology (UST), Republic of Korea

Abstract

In this study, the in-bath coaxial printing technique was used to recapitulate the diameter and wall thickness of a human coronary artery. The resulting tubular structure was cultured using pumpless perfusion and exhibited stentable properties.

Funder

National Research Foundation of Korea

Ministry of Trade, Industry and Energy

Ministry of Agriculture, Food and Rural Affairs

Publisher

Royal Society of Chemistry (RSC)

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