Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe-Reference-Cited by-同舟云学术

Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe

Published:2020 Issue:56 Volume:56 Page:7761-7764
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhu Ning¹²³⁴⁵,Xu Ge¹²³⁴⁵,Wang Rongchen¹²³⁴⁵,Zhu Tianli¹²³⁴⁵,Tan Jiahui⁶⁷⁸⁵⁹,Gu Xianfeng⁶⁷⁸⁵⁹^ORCID,Zhao Chunchang¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center

2. Institute of Fine Chemicals

3. School of Chemistry and Molecular Engineering

4. East China University of Science and Technology

5. Shanghai

6. Department of Medicinal Chemistry

7. School of Pharmacy

8. Fudan University

9. P. R. China

Abstract

A probe with a targetable feature and ratiometric fluorescence as well as NIR emission light-up response to nitroreductase is presented for the precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity.

Funder

National Natural Science Foundation of China

Project 211

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC00494D

Reference37 articles.

1. Mitochondria‐Targeting, Intracellular Delivery of Native Proteins Using Biodegradable Silica Nanoparticles

2. Structure-Guided Design and Synthesis of a Mitochondria-Targeting Near-Infrared Fluorophore with Multimodal Therapeutic Activities

3. A Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Visualizing and Monitoring Viscosity in Live Cells and Tissues

4. Mitochondria‐Targeted Two‐Photon Fluorescent Photosensitizers for Cancer Cell Apoptosis via Spatial Selectability

5. A mitochondria-targeted ratiometric two-photon fluorescent probe for biological zinc ions detection

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