Real-time imaging and quantitative analysis of doxorubicin transport in a perfusable microvessel platform-Reference-Cited by-同舟云学术

Real-time imaging and quantitative analysis of doxorubicin transport in a perfusable microvessel platform

Published:2016 Issue:9 Volume:8 Page:976-984
ISSN:1757-9694
Container-title:Integrative Biology
language:en
Short-container-title:Integr. Biol.

Author:

Bogorad Max I.¹²³⁴⁵,Searson Peter C.¹²³⁴⁵

Affiliation:

1. Institute for Nanobiotechnology

2. Johns Hopkins University

3. Baltimore

4. USA

5. Department of Materials Science and Engineering

Abstract

The kinetics of solute transport across cell monolayers is complex, and often consists of multiple active transport processes in addition to passive diffusion. Here we demonstrate that mechanistic details of transport across biological barriers can be obtained from live cell imaging in a perfusable microvessel model with physiologically relevant geometry.

Funder

American Heart Association

Defense Threat Reduction Agency

National Cancer Institute

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://pubs.rsc.org/en/content/articlepdf/2016/IB/C6IB00082G

Reference42 articles.

1. Coexistence of passive and carrier-mediated processes in drug transport