A cascade indazolone-directed Ir(<scp>iii</scp>)- and Rh(<scp>iii</scp>)-catalyzed C(sp2)–H functionalization/[4 + 2] annulation of 1-arylindazolones with sulfoxonium ylides to access chemically divergent 8H-indazolo [1,2-a]cinnolines-Reference-Cited by-同舟云学术

A cascade indazolone-directed Ir(iii)- and Rh(iii)-catalyzed C(sp²)–H functionalization/[4 + 2] annulation of 1-arylindazolones with sulfoxonium ylides to access chemically divergent 8H-indazolo [1,2-a]cinnolines

Published:2022 Issue:19 Volume:9 Page:5185-5190
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zheng Yi-Chuan¹,Shu Bing²,Zeng Yao-Fu³^ORCID,Chen Shao-Yong¹,Song Jia-Lin¹,Liu Yan-Zhi¹,Xiao Lin¹,Liu Xu-Ge⁴,Zhang Xuanxuan¹,Zhang Shang-Shi¹^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China

2. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China

3. School of Pharmaceutical Science, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, P. R. China

4. School of Pharmacy, Henan University, Kaifeng, Henan 475004, P. R. China

Abstract

An indazolone-directed chemoselective synthesis of 8H-indazolo [1,2-a]cinnolines has been realized via a cascade Cp*Ir(iii)- and Cp*Rh(iii)-catalyzed C–H activation/cyclization reaction of 1-arylindazolones with sulfoxonium ylides.

Funder

Guangdong Pharmaceutical University

National Natural Science Foundation of China

Basic and Applied Basic Research Foundation of Guangdong Province

Medical Science and Technology Foundation of Guangdong Province

Guangzhou Municipal Science and Technology Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00871H