Enantiodivergent synthesis of 1,2-bis(diphenylphosphino)ethanes via asymmetric [3 + 2]-cycloaddition-Reference-Cited by-同舟云学术

Enantiodivergent synthesis of 1,2-bis(diphenylphosphino)ethanes via asymmetric [3 + 2]-cycloaddition

Published:2019 Issue:5 Volume:6 Page:694-698
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Liu Bing¹²³⁴⁵,Li Wenbo¹²³⁴⁵,Wu Hai-Hong¹²³⁴⁵^ORCID,Zhang Junliang⁶⁷⁸⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory of Green Chemistry and Chemical Process

2. School of Chemistry and Molecular Engineering

3. East China Normal University

4. Shanghai 200062

5. China

6. Department of Chemistry

7. Fudan University

8. Shanghai

Abstract

The present work provides efficient access to chiral 1,2-bis(diphenylphosphino)ethanes (DPPEs) directly from diphosphine oxide alkenes and azomethine ylides via asymmetric [3 + 2] cycloaddition. Both enantiomers of the products can be obtained in good to excellent diastereo- and enantioselectivities (up to >20 : 1 dr and 99% ee).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C8QO01404C

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