Clickable styryl dyes for fluorescence labeling of pyrrolidinyl PNA probes for the detection of base mutations in DNA-Reference-Cited by-同舟云学术

Clickable styryl dyes for fluorescence labeling of pyrrolidinyl PNA probes for the detection of base mutations in DNA

Published:2019 Issue:45 Volume:17 Page:9712-9725
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ditmangklo Boonsong¹²³⁴⁵,Taechalertpaisarn Jaru¹²³⁴⁵^ORCID,Siriwong Khatcharin⁶⁷³⁸⁹,Vilaivan Tirayut¹²³⁴⁵^ORCID

Affiliation:

1. Organic Synthesis Research Unit

2. Department of Chemistry

3. Faculty of Science

4. Chulalongkorn University

5. Bangkok 10330

6. Materials Chemistry Research Center

7. Department of Chemistry and Center of Excellence for Innovation in Chemistry

8. Khon Kaen University

9. Khon Kaen 40002

Abstract

Styryl dyes clicked to the backbone of pyrrolidinyl PNA probes show significant fluorescence enhancements in response to structural defects in PNA·DNA duplexes.

Funder

Thailand Research Fund

Chulalongkorn University

National Science and Technology Development Agency

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01492F

Reference71 articles.

1. Nucleic acid-based fluorescent probes and their analytical potential

2. Rationally designed molecular beacons for bioanalytical and biomedical applications

3. Single-Labeled Oligonucleotides Showing Fluorescence Changes upon Hybridization with Target Nucleic Acids

4. Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): Tools for fundamental research, diagnostics, and nanotechnology

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