Development and pilot scale implementation of safe aerobic Cu/TEMPO oxidation in a batch reactor-Reference-Cited by-同舟云学术

Development and pilot scale implementation of safe aerobic Cu/TEMPO oxidation in a batch reactor

Published:2023 Issue:14 Volume:25 Page:5698-5711
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Lemaitre Sylvain¹,Romain Anne-Lise¹,Bariere François¹,Craquelin Anthony¹,Copin Chloé¹,Jean Alexandre¹^ORCID

Affiliation:

1. Industrial Research Centre, Oril Industrie, 13 rue Desgenétais, 76210 Bolbec, France

Abstract

A second generation process for the oxidation of benzylic alcohol 2, involved in the manufacture of Servier clinical candidateS44819, is described. This protocol was safely implemented at a kilogram scale and displays better sustainability compared to the original method.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/GC/D3GC00579H

Reference158 articles.

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4. Development and Process Intensification of an Efficient Flow–Cascade Reaction Sequence in the Synthesis of Afizagabar

5. Metrics to ‘green’ chemistry—which are the best?

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