Stereospecific alkylation of substituted adenines by the Mitsunobu coupling reaction under microwave-assisted conditions-Reference-Cited by-同舟云学术

Stereospecific alkylation of substituted adenines by the Mitsunobu coupling reaction under microwave-assisted conditions

Published:2014 Issue:43 Volume:4 Page:22425-22433
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

García-Rubiño M. E.¹²³⁴,Núñez-Carretero M. C.¹²³⁴,Choquesillo-Lazarte D.⁵⁶⁷⁸,García-Ruiz J. M.⁵⁶⁷⁸,Madrid Yolanda⁹¹⁰¹¹¹²⁴,Campos J. M.¹²³⁴

Affiliation:

1. Departamento de Química Farmacéutica y Orgánica

2. Facultad de Farmacia

3. c/ Campus de Cartuja s/n

4. 18071 Granada, Spain

5. Laboratorio de Estudios Cristalográficos

6. IACT

7. CSIC-Universidad de Granada

8. Granada, Spain

9. Centro de Instrumentación Científica

10. Universidad de Granada

11. Edificio Mecenas

12. Campus Universitario de Fuente Nueva

Abstract

The Mitsunobu reaction under microwave-assisted conditions reveals a complete inversion of the stereogenic centre of the secondary alcohol giving an alkylated purine linked to a homochiral six-membered ring.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA01968G

Reference27 articles.

1. Design, Synthesis and Anticancer Activity Against the MCF-7 Cell Line of Benzo-Fused 1,4-Dihetero Seven- and Six-Membered Tethered Pyrimidines and Purines

2. Acyclonucleosides, Modified Seco-Nucleosides, and Salicyl- or Catechol- Derived Acyclic 5-Fluorouracil O,N-Acetals: Antiproliferative Activities, Cellular Differentiation and Apoptosis

3. New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine

4. Anticancer activity and cDNA microarray studies of a (RS)-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl]-6-chloro-9H-purine, and an acyclic (RS)-O,N-acetalic 6-chloro-7H-purine

5. Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4-benzoxaheteroin-2-ylmethyl)-9H-purines

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