Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment

Author:

Colli Camillo1ORCID,Masi Ilenia2,Jacchetti Emanuela1ORCID,Santoni Silvia13,Sponchioni Mattia1ORCID,Colosimo Bianca Maria3,Rosanò Laura2ORCID,Raimondi Manuela Teresa1ORCID,Mauri Emanuele1ORCID,Moscatelli Davide1ORCID

Affiliation:

1. Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, piazza L. da Vinci 32, 20133 Milan, Italy

2. Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome 00185, Italy

3. Department of Mechanical Engineering, Politecnico di Milano, Via La Masa, 1, 20156, Milan, Italy

Abstract

Through RAFT emulsion polymerization, zwitterionic nanoparticles (NPs) were synthesized as thermally activated drug release systems. Following hyperthermia, drug-loaded NPs outperforms the therapeutic effect of the free drug in ovarian cancer cells.

Funder

European Research Council

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

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