Selective modification of the 3′′-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains-Reference-Cited by-同舟云学术

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Selective modification of the 3′′-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains

Published:2016 Issue:2 Volume:14 Page:516-525
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Santana Andrés G.¹²³⁴,Zárate Sandra G.¹²³⁴,Asensio Juan Luis¹²³⁴,Revuelta Julia¹²³⁴,Bastida Agatha¹²³⁴

Affiliation:

1. CSIC

2. Department of Bioorganic Chemistry

3. 28006-Madrid

4. Spain

Abstract

The N-3′′ modification in the kanamycin A antibiotic prevents significant loss of activity in resistant bacterial strains.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB01599E

Reference48 articles.

1. Aminoglycoside–RNA interactions

2. Strategies for the Design of Drugs Targeting RNA and RNA–Protein Complexes

3. Modulation of RNA function by aminoglycoside antibiotics

4. RNA as a target for small molecules

5. D. Greenwood , Antimicrobial Chemotherapy, Oxford University Press, Oxford, 1995, pp. 32–48

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