Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC Aq/glycopeptide complexes-Reference-Cited by-同舟云学术

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC Aq/glycopeptide complexes

Published:2015 Issue:22 Volume:13 Page:6203-6216
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lindgren Cecilia¹²³⁴,Andersson Ida E.¹²³⁴⁵,Berg Lotta¹²³⁴,Dobritzsch Doreen⁶⁷⁸⁴,Ge Changrong⁵⁹¹⁰¹¹⁴,Haag Sabrina⁵⁹¹⁰¹¹⁴,Uciechowska Urszula¹²³⁴,Holmdahl Rikard⁵⁹¹⁰¹¹⁴,Kihlberg Jan⁶⁷⁸⁴,Linusson Anna¹²³⁴

Affiliation:

1. Department of Chemistry

2. Umeå University

3. SE-901 87 Umeå

4. Sweden

5. Medical Inflammation Research

6. Department of Chemistry – BMC

7. Uppsala University

8. SE-751 23 Uppsala

9. Department of Medical Biochemistry and Biophysics

10. Karolinska Institute

11. SE-171 77 Stockholm

Abstract

Introduction of hydroxyethylene isosteres into glycopeptides led to loss of Aq affinity and subsequent T cell response due to disruption of hydrogen bond networks.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00395D

Reference36 articles.

1. The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

2. Utility of animal models for identification of potential therapeutics for rheumatoid arthritis

3. Expression of a transgenic class IIAb gene confers susceptibility to collagen-induced arthritis

4. T Cells Recognize a Glycopeptide Derived from Type II Collagen in a Model for Rheumatoid Arthritis

5. Therapeutic Vaccination of Active Arthritis with a Glycosylated Collagen Type II Peptide in Complex with MHC Class II Molecules

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chemical synthesis and functional evaluation of glycopeptides and glycoproteins containing rare glycosyl amino acid linkages;Natural Product Reports;2024

2. ANALYSIS OF CARBOHYDRATES AND GLYCOCONJUGATES BY MATRIX‐ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY: AN UPDATE FOR 2015–2016;Mass Spectrometry Reviews;2021-03-16

3. Syntheses of SGLT2 Inhibitors by Ni- and Pd-Catalyzed Fukuyama Coupling Reactions;The Journal of Organic Chemistry;2020-09-11

4. Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis;Journal of Medicinal Chemistry;2018-05-04

5. Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis;The Journal of Immunology;2017-11-10