HFIP-mediated 2-aza-Cope rearrangement: metal-free synthesis of α-substituted homoallylamines at ambient temperature-Reference-Cited by-同舟云学术

HFIP-mediated 2-aza-Cope rearrangement: metal-free synthesis of α-substituted homoallylamines at ambient temperature

Published:2021 Issue:18 Volume:19 Page:4067-4075
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Gadde Karthik¹²³⁴^ORCID,Maes Bert U. W.¹²³⁴^ORCID,Abbaspour Tehrani Kourosch¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Antwerp

3. B-2020 Antwerp

4. Belgium

Abstract

A synthesis of α-substituted homoallylamine derivatives is presented, involving the in situ generation of aldimines from readily available aldehydes and 1,1-diphenylhomoallylamines, followed by a 2-aza-Cope rearrangement in HFIP at room temperature.

Funder

Universiteit Antwerpen

Herculesstichting

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00404B

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