Enantioselective synthesis of trifluoromethylated dihydroquinoxalinones via palladium-catalyzed hydrogenation-Reference-Cited by-同舟云学术

Enantioselective synthesis of trifluoromethylated dihydroquinoxalinones via palladium-catalyzed hydrogenation

Published:2019 Issue:6 Volume:6 Page:746-750
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Chen Mu-Wang¹²³⁴⁵^ORCID,Deng Zhihong¹²³⁴⁵,Yang Qin¹²³⁴⁵,Huang Jian¹²³⁴⁵,Peng Yiyuan¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Small Functional Organic Molecule

2. Ministry of Education

3. Jiangxi's Key Laboratory of Green Chemistry and College of Chemistry & Chemical Engineering

4. Jiangxi Normal University Nanchang

5. Jiangxi 330022

Abstract

A highly enantioselective palladium-catalyzed asymmetric hydrogenation of 3-(trifluoromethyl)quinoxalinones has been successfully developed, providing a general and facile access to chiral 3-(trifluoromethyl)-3,4-dihydroquinoxalinones with up to 99% ee.

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

Dalian University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C8QO01361F

Reference61 articles.

1. Antagonist, Partial Agonist, and Full Agonist Imidazo[1,5-a]quinoxaline Amides and Carbamates Acting through the GABAA/Benzodiazepine Receptor