Study on the signaling pathways involved in the anti-hyperglycemic effect of raspberry ketone on zebrafish using integrative transcriptome and metabolome analyses

Author:

Zhu Xinliang12ORCID,Zhang Dengcai3,Wang Yong4,Wang Chuangxin1,Liu Xiaoxiao5,Niu Yicong6

Affiliation:

1. College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu Province, China

2. Department of Scientific Research, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China

3. Department of Pathology, Gansu Provincial Maternity and Health Care Hospital, Lanzhou 730000, Gansu Province, China

4. Pathology Center, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

5. Lanzhou Institute of Food and Drug Control, Lanzhou 740050, Gansu Province, China

6. The First Hospital of Lanzhou University, Department of General Surgery, Lanzhou 730000, Gansu, China

Abstract

Raspberry ketone alleviated hyperglycemia via regulating insulin synthesis and secretion pathways and homeostasis of purine metabolism in a zebrafish hyperglycemia model.

Funder

Gansu Education Department

Natural Science Foundation of Gansu Province

Publisher

Royal Society of Chemistry (RSC)

Reference47 articles.

1. I. D.Atlas , Brussels, Belgium: international diabetes federation; 2013 , International Diabetes Federation (IDF) , 2017 , vol. 147

2. The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

3. Pathophysiology of Type 2 Diabetes Mellitus

4. Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

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