Image fusion of IR and optical microscopy for mapping of biomolecules in tissue-Reference-Cited by-同舟云学术

Image fusion of IR and optical microscopy for mapping of biomolecules in tissue

Published:2021 Issue:19 Volume:146 Page:5848-5854
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Al Jedani Safaa¹,Whitley Conor A.¹,Ellis Barnaby G.¹,Triantafyllou Asterios²^ORCID,Smith Caroline I.¹^ORCID,Gunning Philip J.³^ORCID,Gardner Peter⁴^ORCID,Risk Janet M.³^ORCID,Weightman Peter¹^ORCID,Barrett Steve D.¹^ORCID

Affiliation:

1. Department of Physics, University of Liverpool, L69 7ZE, UK

2. Department of Pathology, Liverpool Clinical Laboratories, University of Liverpool, Liverpool, L69 3GA, UK

3. Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L3 9TA, UK

4. Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

Abstract

We demonstrate image fusion of H&E stains (left) with FTIR images (centre) to create fused images (right) that have both the spatial resolution of the H&E and the chemical information of the FTIR.

Funder

Cancer Research UK

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/AN/D1AN01161H

Reference35 articles.

1. Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

2. Advances in Fourier transform infrared (FTIR) spectroscopy of biological tissues