pH-Sensitive nanogates based on poly(l-histidine) for controlled drug release from mesoporous silica nanoparticles

Author:

Bilalis Panayiotis1234,Tziveleka Leto-A.15634,Varlas Spyridon1234,Iatrou Hermis1234

Affiliation:

1. University of Athens

2. Department of Chemistry

3. Athens

4. Greece

5. Department of Pharmacognosy and Chemistry of Natural Products

6. Faculty of Pharmacy

Abstract

Mesoporous silica nanoparticles (MSNs) bearing poly(l-histidine)-grafted nanogates were prepared by surface-initiated ROP. The obtained polypeptide-functionalized MSNs were used as smart pH-responsive nanocarriers for controlled drug release applications.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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