Synthesis, characterisation and in vitro cytotoxicity of mixed ligand Pt(ii) oxadiazoline complexes with hexamethylenetetramine and 7-nitro-1,3,5-triazaadamantane

Author:

Sieste Stefanie1234,Lifincev Irina1234,Stein Nina1234,Wagner Gabriele12345ORCID

Affiliation:

1. Institute of Inorganic Chemistry

2. University of Ulm

3. D-89081 Ulm

4. Germany

5. Department of Natural Sciences

Abstract

The synthesis, spectroscopic and DFT-computational characterisation of trans-Pt(ii) oxadiazoline complexes is described. Some are more cytotoxic in vitro than cisplatin with the human cancer cell lines HeLa and A549.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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4. The resurgence of platinum-based cancer chemotherapy

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