1,2-Disubstituted bicyclo[2.1.1]hexanes as saturated bioisosteres of <i>ortho</i>-substituted benzene-Reference-Cited by-同舟云学术

1,2-Disubstituted bicyclo[2.1.1]hexanes as saturated bioisosteres of ortho-substituted benzene

Published:2023 Issue:48 Volume:14 Page:14092-14099
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Denisenko Aleksandr¹,Garbuz Pavel¹,Makovetska Yelyzaveta¹,Shablykin Oleh¹²,Lesyk Dmytro³,Al-Maali Galeb¹⁴,Korzh Rodion¹,Sadkova Iryna V.¹,Mykhailiuk Pavel K.¹^ORCID

Affiliation:

1. Enamine Ltd, Winston Churchill st. 78, 02094 Kyiv, Ukraine

2. V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 02094 Kyiv, Ukraine

3. Bienta, Winston Churchill st. 78, 02094 Kyiv, Ukraine

4. Institute of Botany of the National Academy of Sciences of Ukraine, 02094 Kyiv, Ukraine

Abstract

1,2-Disubstituted bicyclo[2.1.1]hexanes have been synthesized, characterized, and biologically validated as saturated bioisosteres of the ortho-substituted benzene ring.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC05121H

Reference40 articles.

1. Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds

2. Rings in Drugs

3. Rings in Clinical Trials and Drugs: Present and Future