Biocatalytic and chemical derivatization of the fungal meroditerpenoid chevalone E

Author:

Xiao Zong-Hua1,Dong Jia-Yu1,Li Ao2,Dai Jia-Meng1,Li Yan-Ping3,Hu Qiu-Fen1,Shao Li-Dong3ORCID,Matsuda Yudai4ORCID,Wang Wei-Guang1ORCID

Affiliation:

1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education and Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission, Yunnan Minzu University, Kunming 650031, China

2. Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China

3. Yunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, China

4. Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China

Abstract

The structural derivatization of the fungal meroditerpenoid chevalone E was achieved by biocatalytic and chemical approaches. Some of the new chevalone analogues, in combination with doxorubicin, synergistically inhibit the growth of breast cancer cells.

Funder

Natural Science Foundation of Yunnan Province

Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province

Research Grants Council, University Grants Committee

Basic and Applied Basic Research Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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