Cocrystallization of lenvatinib and temozolomide to improve the performance in terms of stability, dissolution, and tabletability-Reference-Cited by-同舟云学术

Cocrystallization of lenvatinib and temozolomide to improve the performance in terms of stability, dissolution, and tabletability

Published:2023 Issue:29 Volume:25 Page:4189-4198
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Wang Zhi-Qing¹,Dai Xia-Lin¹,Gu Dai-Lin¹,Wu Chao¹,Lu Tong-Bu²^ORCID,Long Xiang-Tian³,Chen Jia-Mei¹^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China

2. Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China

3. Tasly Academy, Tasly Holding Group Co., Ltd, Tianjin 300410, China

Abstract

Cocrystallization of two anti-melanoma drugs, lenvatinib and temozolomide, resulted in two drug–drug cocrystal solvates presenting improved performance in terms of stability, dissolution, and tabletability, which show great potential to be developed as a drug combination.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CE/D3CE00473B

Reference34 articles.

1. Metastatic Behavior in Melanoma: Timing, Pattern, Survival, and Influencing Factors

2. Primary Melanoma Characteristics of Metastatic Disease: A Nationwide Cancer Registry Study

3. Chemotherapy for Melanoma

4. The natural FGF-trap long pentraxin 3 inhibits lymphangiogenesis and lymphatic dissemination

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