Stability of a half-sandwich Os(<scp>ii</scp>) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A-Reference-Cited by-同舟云学术

Stability of a half-sandwich Os(ii) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A

Published:2022 Issue:24 Volume:51 Page:9213-9217
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Masaryk Lukáš¹,Muthná Darina²,Halaš Petr¹,Zoufalý Pavel¹,Peterová Eva²,Havelek Radim²^ORCID,Drahoš Bohuslav¹^ORCID,Milde David³^ORCID,Mrkvicová Alena²,Štarha Pavel¹^ORCID

Affiliation:

1. Department of Inorganic Chemistry, Faculty of Science, Palacky University in Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic

2. Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Šimkova 870, 500 03 Hradec Kralove, Czech Republic

3. Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic

Abstract

The hydrolytically stable half-sandwich complex [Os(η6-pcym)(L2)Cl]PF6 (2) partially releases the bioactive substituent indomethacin in the presence of carboxypeptidase A.

Funder

Univerzita Palackého v Olomouci

Univerzita Karlova v Praze

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D2DT01085B

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5. Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

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