Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer-Reference-Cited by-同舟云学术

Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer

Published:2024 Issue:9 Volume:12 Page:2292-2301
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Mi Shiwei¹²,Li Wei¹²,Wen Yixing¹²,Yang Chen¹²,Liu Shuai¹,Li Jingjiao¹²,Cheng Xingdi¹²,Zhao Yuanyuan¹²,Huo Haonan¹²,Zu Haowei¹,Lu Xueguang¹²^ORCID

Affiliation:

1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

ATRA and CpG are co-delivered by LbL nanoparticles, inducing the homing of activated T cells to the gut. Injecting NPs with OVA peptide effectively inhibits orthotopic colorectal tumor growth in mice without causing noticeable side effects.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D4BM00026A

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1. Cancer statistics, 2022

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3. Cancer immunotherapy comes of age

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