Biosynthesis of a new skyllamycin in <i>Streptomyces nodosus</i>: a cytochrome P450 forms an epoxide in the cinnamoyl chain-Reference-Cited by-同舟云学术

Biosynthesis of a new skyllamycin in Streptomyces nodosus: a cytochrome P450 forms an epoxide in the cinnamoyl chain

Published:2024 Issue:14 Volume:22 Page:2835-2843
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Song Yuhao¹^ORCID,Amaya Jose A.²,Murarka Vidhi C.²^ORCID,Mendez Hugo²,Hogan Mark¹^ORCID,Muldoon Jimmy³^ORCID,Evans Paul³^ORCID,Ortin Yannick³^ORCID,Kelly Steven L.⁴,Lamb David C.⁴,Poulos Thomas L.²,Caffrey Patrick¹^ORCID

Affiliation:

1. Centre for Synthesis and Chemical Biology and School of Biomolecular and Biomedical Science, University College Dublin, Ireland

2. Departments of Molecular Biology and Biochemistry, Pharmaceutical Sciences and Chemistry, University of California, Irvine, California, USA

3. Centre for Synthesis and Chemical Biology and School of Chemistry, University College Dublin, Ireland

4. Faculty of Medicine, Health and Life Science, Institute of Life Science, Swansea University, Singleton Park, Swansea, SA2 8PP, UK

Abstract

Gene disruption identifies a class of cytochrome P450s that form epoxides in acyl chains of substituted cinnamoyl-containing natural products.

Funder

European Regional Development Fund

Irish Research Council

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00178H

Reference46 articles.

1. Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain

2. Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation and biological activity.

3. Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster

4. Coprisamides A and B, New Branched Cyclic Peptides from a Gut Bacterium of the Dung Beetle Copris tripartitus

5. New WS9326A Congeners from Streptomyces sp. 9078 Inhibiting Brugia malayi Asparaginyl-tRNA Synthetase

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