Calcium signaling on Jurkat T cells induced by microbeads coated with novel peptide ligands specific to human CD3ε-Reference-Cited by-同舟云学术

Calcium signaling on Jurkat T cells induced by microbeads coated with novel peptide ligands specific to human CD3ε

Published:2021 Issue:6 Volume:9 Page:1661-1675
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Ahmadi Armin¹²³⁴,Ayyadevara V. S. S. Abhinav⁵²³⁴^ORCID,Baudry Jerome⁵²³⁴⁶,Roh Kyung-Ho¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemical & Materials Engineering

2. University of Alabama in Huntsville

3. Huntsville

4. USA

5. Biotechnology Science and Engineering

6. Department of Biological Sciences

Abstract

Magnetic microbeads decorated with novel peptide ligands against human CD3ε can activate the Jurkat T cells via specific T cell receptor (TCR) signaling pathways linked to calcium flux, IL-2 secretion, and cell proliferation.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2021/TB/D0TB02235G

Reference76 articles.

1. THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

2. The T-Cell Antigen Receptor.

3. Structural Model of the Extracellular Assembly of the TCR-CD3 Complex

4. Molecular architecture of the αβ T cell receptor–CD3 complex

5. Deconstructing the Form and Function of the TCR/CD3 Complex

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