Quantification of nanoscale forces in lectin-mediated bacterial attachment and uptake into giant liposomes

Author:

Omidvar Ramin12345ORCID,Ayala Yareni A.6274,Brandel Annette12345,Hasenclever Lukas12345,Helmstädter Martin89101112ORCID,Rohrbach Alexander6274,Römer Winfried12345ORCID,Madl Josef12345ORCID

Affiliation:

1. Faculty of Biology

2. University of Freiburg

3. 79104 Freiburg

4. Germany

5. Signalling Research Centres BIOSS and CIBSS

6. Department of Microsystems Engineering (IMTEK)

7. 79110 Freiburg

8. Renal Division

9. Department of Medicine

10. University Hospital Freiburg

11. Freiburg University Faculty of Medicine

12. Freiburg

Abstract

Two force probing methods were used to quantify nanoscale forces in the interaction of the bacterial lectin LecA with the glycolipid Gb3, revealing how the interaction aids bacterial attachment and lowers the energy required for bacterial uptake.

Funder

Albert-Ludwigs-Universität Freiburg

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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