Design of small molecules targeting RNA structure from sequence-Reference-Cited by-同舟云学术

Design of small molecules targeting RNA structure from sequence

Published:2020 Issue:20 Volume:49 Page:7252-7270
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Ursu Andrei¹²³⁴,Childs-Disney Jessica L.¹²³⁴,Andrews Ryan J.⁵⁶⁷⁸⁴^ORCID,O’Leary Collin A.⁵⁶⁷⁸⁴^ORCID,Meyer Samantha M.¹²³⁴,Angelbello Alicia J.¹²³⁴,Moss Walter N.⁵⁶⁷⁸⁴,Disney Matthew D.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. The Scripps Research Institute

3. Jupiter

4. USA

5. Roy J. Carver Department of Biochemistry

6. Biophysics & Molecular Biology

7. Iowa State University

8. Ames

Abstract

Herein, we describe methods to identify structured regions within disease-causing RNAs and to design lead small molecules that selectively bind these structures to modulate function.

Funder

National Institute of Neurological Disorders and Stroke

National Cancer Institute

U.S. Department of Defense

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CS/D0CS00455C

Reference50 articles.