Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile-Reference-Cited by-同舟云学术

Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile

Published:2020 Issue:75 Volume:56 Page:11018-11021
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Xiang Junhong¹²³⁴⁵,Zhang Xuemei⁶⁷⁵,Wang Dehong¹²³⁴⁵,Li Jiaxin¹²³⁴⁵,Li Qiuying¹²³⁴⁵,Wang Qin¹²³⁴⁵,Ding Yahui¹²³⁴⁵,Chen Tianyang¹²³⁴⁵,Sun Yuanjun⁸⁹¹⁰⁵,Bao Shiqi⁶⁷⁵,Chen Jing⁶⁷⁵,Li Dongmei¹²³⁴⁵,Wang Liang¹²³⁴⁵,Chen Yue¹²³⁴⁵^ORCID

Affiliation:

1. The State Key Laboratory of Medicinal Chemical Biology

2. College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research

3. Nankai University

4. Tianjin 300071

5. China

6. Accendatech Company, Ltd

7. Tianjin 300384

8. College of Pharmaceutical Sciences

9. Soochow University Medical College

10. Suzhou 215123

Abstract

Stepwise modification of ovatodiolide revealed a prodrug NMP-diepoxyovatodiolide, which is a very promising candidate for further development of liver-related drugs.

Funder

National Natural Science Foundation of China

National Science Fund for Distinguished Young Scholars

Nankai University

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC07573A

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