PROTAC degraders as chemical probes for studying target biology and target validation-Reference-Cited by-同舟云学术

PROTAC degraders as chemical probes for studying target biology and target validation

Published:2022 Issue:18 Volume:51 Page:7971-7993
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Němec Václav¹²^ORCID,Schwalm Martin P.¹²^ORCID,Müller Susanne¹²^ORCID,Knapp Stefan¹²³^ORCID

Affiliation:

1. Institut für Pharmazeutische Chemie, Goethe-University Frankfurt, Biozentrum, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany

2. Structural Genomics Consortium, Goethe-University Frankfurt, Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany

3. German Cancer Consortium (DKTK)/German Cancer Research Center (DKFZ), DKTK site Frankfurt-Mainz, 69120 Heidelberg, Germany

Abstract

This review provides guidelines for the optimization of proteolysis targeting chimeras (PROTACs) and outlines criteria for their use as chemical probes.

Funder

Deutsche Forschungsgemeinschaft

Bayer

Boehringer Ingelheim

Genome Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CS/D2CS00478J

Reference125 articles.