Quasi-3D morphology and modulation of focal adhesions of human adult stem cells through combinatorial concave elastomeric surfaces with varied stiffness

Author:

Portone A.1234,Sciancalepore A. G.5674,Melle G.891074,Netti G. S.111213144,Greco G.1234,Persano L.1234,Gesualdo L.1516174,Pisignano D.18192034ORCID

Affiliation:

1. NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore

2. Piazza S. Silvestro 12

3. I-56127 Pisa

4. Italy

5. Istituto Microelettronica e Microsistemi-CNR

6. Via Monteroni

7. I-73100 Lecce

8. Dipartimento di Scienze e Tecnologie Biologiche e Ambientali

9. Università del Salento

10. via provinciale per Monteroni

11. Clinical Pathology Unit

12. Department of Medical and Surgical Sciences

13. University of Foggia

14. I-71121 Foggia

15. Nephrology, Dialysis and Transplantation Unit

16. Department of Emergency and Organ Transplantation

17. I-70121 Bari

18. Dipartimento di Fisica

19. Università di Pisa

20. Largo B. Pontecorvo 3

Abstract

Concave surface topography led stem cells in a quasi-three dimensional configuration where stiffness steers mechanosensing highlighted by focal adhesion properties.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

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